In addition to what @betatim said you might find this forum thread interesting:
I think it’s also worth stepping back and asking “What is your ultimate goal?”, as this may affect whether modifying BinderHub is the right choice, or whether we’re looking for a new application inspired by BinderHub but with much bigger aims.
Do you want a way to dynamically spin up and destroy environments with automatic installation of dependencies? Are these environments conda environments, containers, VMs, or something else? Does it have to be fully automated, or is it ok to give the user a blank environment and tell them to run repo2something to install some dependencies?
Two of the big advantages of binderhub are it requires very little knowledge on the part of the user to obtain an environment where they can run stuff, and its reproduciblity. Is this what HPC users want, or are the limitations of a fixed disposable environment likely to be frustrating given they probably have above average coding skills?
Edit: Another interesting thread: